Jenkins R G, Friedel R O
J Pharm Sci. 1978 Jan;67(1):17-23. doi: 10.1002/jps.2600670106.
A method is described for the analysis of amitriptyline, doxepin, imipramine, nortriptyline, desmethyldoxepin, desipramine, and protriptyline in human plasma utlizing GLC-chemical-ionization mass spectrometry with selected ion monitoring. The assay is highly specific and is quantitative to at least 1 ng/ml with a standard error typically less than 5%. Representative concentrations of the parent compounds and their monodemethylated metabolites, as meeasured in plasma samples from patients under treatment with tertiary amine tricyclic antidepressants, are given.
描述了一种利用气相色谱 - 化学电离质谱法和选择离子监测技术分析人血浆中阿米替林、多塞平、丙咪嗪、去甲替林、去甲基多塞平、地昔帕明和普罗替林的方法。该测定法具有高度特异性，定量下限至少为1 ng/ml，标准误差通常小于5%。给出了在接受叔胺三环类抗抑郁药治疗的患者血浆样本中测得的母体化合物及其单去甲基代谢物的代表性浓度。
