Schuler G, Romani N, Stingl G, Wolff K
Ultrastruct Pathol. 1983 Jul;5(1):77-82. doi: 10.3109/01913128309141821.
Histiocytosis X cells (HXC) and epidermal Langerhans cells (LC) are thought to be closely related because they share morphologic features and immunologic markers. One of these common markers, the LC granule, is an acknowledged morphologic criterion for the identification of these cell types, but its function and, thus, significance are as yet unknown. In this study, we report the presence of a fuzzy coat radiating from the cytoplasmic face of the LC granule membrane in HXC. This bristly coat is indistinguishable from that of coated vesicles and pits and, thus, represents a strong morphologic clue to the function of LC granules because coated structures have been shown to be involved in the selective transport of molecules in eukaryotic cells.
组织细胞增多症X细胞（HXC）和表皮朗格汉斯细胞（LC）被认为密切相关，因为它们具有共同的形态学特征和免疫标记物。这些共同标记物之一，即LC颗粒，是识别这些细胞类型的公认形态学标准，但其功能以及因此具有的意义尚不清楚。在本研究中，我们报告在HXC中存在从LC颗粒膜的胞质面辐射出的模糊被膜。这种刚毛状被膜与被膜小泡和小窝的被膜无法区分，因此是LC颗粒功能的一个有力形态学线索，因为已表明被膜结构参与真核细胞中分子的选择性运输。
