炔雌醇对兔血小板中花生四烯酸掺入、释放及转化为前列腺素的影响。

Effect of ethinylestradiol on arachidonic acid incorporation, release, and conversion to prostaglandins in rabbit platelets.

作者信息

Skjaerlund J M, Gallon L, Subbiah M T

出版信息

Biochem Med. 1983 Dec;30(3):357-62. doi: 10.1016/0006-2944(83)90028-5.

Abstract

Intramuscular administration to female rabbits of 2 mg/kg ethinylestradiol every other day for 10 days increased the uptake and incorporation of [14C]arachidonic acid into platelet lipids, and increased the proportion of [14C]arachidonic acid released from platelets after stimulation by thrombin. The conversion of [14C]arachidonic acid to thromboxane B2 did not differ between the control and ethinylestradiol-treated groups. Thus, the results of this study indicate that the major site in the prostaglandin metabolic pathway influenced by estrogen is the incorporation and release of arachidonic acid in platelet phospholipids.

摘要

每隔一天给雌性兔子肌肉注射2毫克/千克乙炔雌二醇，持续10天，这增加了[14C]花生四烯酸在血小板脂质中的摄取和掺入，并增加了凝血酶刺激后血小板释放的[14C]花生四烯酸的比例。在对照组和乙炔雌二醇处理组之间，[14C]花生四烯酸向血栓素B2的转化没有差异。因此，本研究结果表明，雌激素影响的前列腺素代谢途径的主要部位是花生四烯酸在血小板磷脂中的掺入和释放。