Stillman R J, Williams R F, Lynch A, Hodgen G D
Fertil Steril. 1983 Dec;40(6):823-8. doi: 10.1016/s0015-0282(16)47488-1.
Nonsteroidal factor(s) in porcine follicular fluid (pFF) can selectively suppress tonic follicle-stimulating hormone (FSH) concentrations when administered in the follicular phase to monkeys. Here it is demonstrated that when administered in either the early follicular phase or in the midst of the spontaneous preovulatory estradiol (E2) surge (E2 greater than or equal to 200 pg/ml), pFF preferentially inhibits FSH or blocks the FSH surge, respectively, whereas immunoassayable and bioassayable luteinizing hormone (LH) surges persist. Delay in the timing of ovulation uniformly follows follicular phase pFF administration, and corpus luteal insufficiency is often seen. The inhibitions of FSH in circulation were achieved by a decrease in amplitude and frequency of FSH pulses. No discernible effect on LH pulsatility was observed.
猪卵泡液（pFF）中的非甾体因子在卵泡期给予猴子时，可选择性抑制促卵泡激素（FSH）的基础浓度。本文证明，在卵泡早期或自发排卵前雌二醇（E2）激增期间（E2大于或等于200 pg/ml）给予pFF时，pFF分别优先抑制FSH或阻断FSH激增，而可免疫测定和生物测定的促黄体生成素（LH）激增持续存在。卵泡期给予pFF后，排卵时间均延迟，且常出现黄体功能不全。循环中FSH的抑制是通过降低FSH脉冲的幅度和频率实现的。未观察到对LH脉冲性有明显影响。
