Kiso Y, Tohkin M, Hikino H
J Nat Prod. 1983 Sep-Oct;46(5):651-4. doi: 10.1021/np50029a010.
Extracts of various samples of the crude drug prepared from Atractylodes rhizomes exhibited antihepatotoxic activity by in vitro assay methods using carbon tetrachloride- and galactosamine-induced cytotoxicity in primary cultured rat hepatocytes. The main sesquiterpenoid components were subjected to screening by these methods to reveal that atractylon, beta-eudesmol, and hinesol exerted significant liver-protective effects. Some analogs were also assayed.
采用四氯化碳和半乳糖胺诱导原代培养大鼠肝细胞产生细胞毒性的体外检测方法，对白术根茎粗提物的各种样品提取物进行检测，结果显示其具有抗肝毒性活性。通过这些方法对主要倍半萜类成分进行筛选，结果表明苍术酮、β-桉叶醇和广藿香醇具有显著的肝脏保护作用。还对一些类似物进行了检测。
