Hikino H, Kiso Y, Hatano T, Yoshida T, Okuda T
J Ethnopharmacol. 1985 Sep;14(1):19-29. doi: 10.1016/0378-8741(85)90024-8.
The antihepatotoxic effects of tannin analogues were examined utilizing carbon tetrachloride- and galactosamine-induced cytotoxicity in primary cultured rat hepatocytes. Most tannins showed significant antihepatotoxic effects in these two assay systems. Hydrolyzable tannins generally exhibited an intense enzyme inhibitory action on glutamic-pyruvic transaminase while condensed tannins exerted a much less inhibitory action, although variations were observed depending on structure. Structure-activity relationships are discussed.
利用四氯化碳和半乳糖胺诱导原代培养大鼠肝细胞产生细胞毒性，研究了单宁类似物的抗肝毒性作用。在这两种检测系统中，大多数单宁显示出显著的抗肝毒性作用。可水解单宁通常对谷丙转氨酶表现出强烈的酶抑制作用，而缩合单宁的抑制作用则小得多，不过根据结构不同也存在差异。文中讨论了构效关系。
