柯桠根的抗肝毒性作用。

Antihepatotoxic actions of Cochlospermum tinctorium rhizomes.

作者信息

Diallo B, Vanhaelen M, Kiso Y, Hikino H

机构信息

Laboratoire de Pharmacognosie, Université libre de Bruxelles, Belgium.

出版信息

J Ethnopharmacol. 1987 Aug;20(3):239-43. doi: 10.1016/0378-8741(87)90051-1.

DOI:10.1016/0378-8741(87)90051-1

PMID:3682848

Abstract

The antihepatotoxic activity of the rhizomes of Cochlospermum tinctorium was investigated using carbon tetrachloride- and galactosamine-induced cytotoxicity in primary cultured rat hepatocytes. Because the methanol and ethanol extracts of C. tinctorium rhizomes exhibited antihepatotoxic effects, the former was fractionated in order to elucidate the active constituents. Polyphenol compounds (gallic and ellagic acids) were detected in the active fractions and may account for much of the antihepatotoxic activity. Carotenoids could also be implicated in the activity of the total extracts.

摘要

利用四氯化碳和半乳糖胺诱导原代培养大鼠肝细胞产生细胞毒性，对黄栌根茎的抗肝毒性活性进行了研究。由于黄栌根茎的甲醇提取物和乙醇提取物均表现出抗肝毒性作用，因此对前者进行了分离，以阐明其活性成分。在活性组分中检测到了多酚化合物（没食子酸和鞣花酸），它们可能是抗肝毒性活性的主要原因。类胡萝卜素也可能与总提取物的活性有关。