Globus M, Keren A, Eldad M, Granot C, Tzivoni D, Lavy S, Stern S
Stroke. 1983 Nov-Dec;14(6):964-7. doi: 10.1161/01.str.14.6.964.
In 31 hypertensive patients the effect of chronic oral administration of the beta blocking agent propranolol on regional cerebral blood flow (rCBF) was studied, using the non-invasive 133Xenon inhalation technique. The results of the measurements were compared to the rCBF obtained in an age-matched normal control group. Our study shows that during long-term therapy with low doses of propranolol (less than 120 mg/daily) the rCBF is unaffected, but it is increased significantly if higher doses (greater than 120 mg/daily) are used. In all six patients who served as their own control, as they had basic rCBF measurements before or during low-dose propranolol, the rCBF on high-dose propranolol became significantly increased. The possible mechanisms which may cause the increased rCBF on high-dose propranolol are discussed.
采用非侵入性氙-133吸入技术，研究了31例高血压患者长期口服β受体阻滞剂普萘洛尔对局部脑血流量（rCBF）的影响。将测量结果与年龄匹配的正常对照组的rCBF进行比较。我们的研究表明，在长期使用低剂量普萘洛尔（每日小于120毫克）治疗期间，rCBF不受影响，但如果使用更高剂量（每日大于120毫克），rCBF会显著增加。在6例作为自身对照的患者中，由于他们在低剂量普萘洛尔治疗前或治疗期间进行了基础rCBF测量，高剂量普萘洛尔治疗时的rCBF显著增加。文中讨论了高剂量普萘洛尔导致rCBF增加的可能机制。
