Bes A, Dupui P, Guell A, Géraud G
Arch Mal Coeur Vaiss. 1986 Jun;79(6):977-9.
In 17 moderate hypertensive patients (mean age = 67 +/- 8.8) the effects of a chronic oral administration of the beta blocking agent acebutolol on regional cerebral blood flow (rCBF) was studied using the non invasive 133 Xenon inhalation technique. The results was compared to the rCBF obtained in an age matched normal control group. Our study shows that during long term therapy low doses of acebutolol (200 mg/daily) the rCBF is unaffected by a decrease (20 mmHg) of the mean arterial blood pressure. The relative hypofrontality of the elderly hypertensive patients leads to be corrected by acebutolol.
在17例中度高血压患者（平均年龄 = 67 ± 8.8岁）中，采用无创性氙-133吸入技术研究了长期口服β受体阻滞剂醋丁洛尔对局部脑血流量（rCBF）的影响。将结果与年龄匹配的正常对照组的rCBF进行比较。我们的研究表明，在长期治疗期间，低剂量醋丁洛尔（200毫克/日）时，rCBF不受平均动脉血压降低（20毫米汞柱）的影响。老年高血压患者相对的额叶低灌注可被醋丁洛尔纠正。
