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[单次注射肝癌致癌物4-二甲基氨基偶氮苯及其非致癌类似物后大鼠肝脏中低分化细胞的增殖]

[Proliferation of poorly differentiated cells in the rat liver after a single injection of the hepatocarcinogen 4-dimethylaminoazobenzine and its noncarcinogenic analog].

作者信息

Medvedeva N D, Antipanova E M

出版信息

Tsitologiia. 1983 Nov;25(11):1333-5.

PMID:6419425
Abstract

With the aid of autoradiography, the proliferation of non-differentiated (oval and transitional) cells in rat liver induced by a single injection of hepatocarcinogen 4-dimethylaminoazobenzene and its non-carcinogenic analogue has been studied. These cells are characterized by a high proliferative activity reaching its maximum 4 days after injection of both the agents. Later on, the proliferative activity decreased due probably to differentiation of such cells.

摘要

借助放射自显影技术,研究了单次注射肝癌致癌物4-二甲基氨基偶氮苯及其非致癌类似物后大鼠肝脏中未分化(椭圆形和过渡型)细胞的增殖情况。这些细胞的特点是增殖活性高,在注射这两种试剂后4天达到最大值。随后,增殖活性可能由于这些细胞的分化而降低。

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