[单次致癌暴露后大鼠肝脏抗原结构变化的评估]
[Evaluation of the antigenic structural changes in the rat liver after a single carcinogenic exposure].
作者信息
Ivanov V A, Belisheva N K, Iakobidze V E, Fel' V Ia
出版信息
Tsitologiia. 1979 Jul;21(7):836-41.
PMID:90416
Abstract
A single injection of hepatocarcinogen (4-dimethylaminoazobenzene) to rats resulted in antigenic rearrangement in rat liver, typical of hepatocellular tumors, whereas the treatment with a non-carcinogen isomere (4-diethylaminoazobenzene) did not have the same effect. It is assumed that antigenic rearrangement in hepatocytes caused by 4-dimethylaminoazobenzene might be due to its carcinogenity.
摘要
给大鼠单次注射肝癌致癌物（4-二甲基氨基偶氮苯）会导致大鼠肝脏发生抗原重排，这是肝细胞肿瘤的典型特征，而用非致癌异构体（4-二乙氨基偶氮苯）进行治疗则没有相同效果。据推测，4-二甲基氨基偶氮苯引起的肝细胞抗原重排可能归因于其致癌性。
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