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[单次致癌暴露后大鼠肝脏抗原结构变化的评估]

[Evaluation of the antigenic structural changes in the rat liver after a single carcinogenic exposure].

作者信息

Ivanov V A, Belisheva N K, Iakobidze V E, Fel' V Ia

出版信息

Tsitologiia. 1979 Jul;21(7):836-41.

PMID:90416
Abstract

A single injection of hepatocarcinogen (4-dimethylaminoazobenzene) to rats resulted in antigenic rearrangement in rat liver, typical of hepatocellular tumors, whereas the treatment with a non-carcinogen isomere (4-diethylaminoazobenzene) did not have the same effect. It is assumed that antigenic rearrangement in hepatocytes caused by 4-dimethylaminoazobenzene might be due to its carcinogenity.

摘要

给大鼠单次注射肝癌致癌物（4-二甲基氨基偶氮苯）会导致大鼠肝脏发生抗原重排，这是肝细胞肿瘤的典型特征，而用非致癌异构体（4-二乙氨基偶氮苯）进行治疗则没有相同效果。据推测，4-二甲基氨基偶氮苯引起的肝细胞抗原重排可能归因于其致癌性。

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[Evaluation of the antigenic structural changes in the rat liver after a single carcinogenic exposure].[单次致癌暴露后大鼠肝脏抗原结构变化的评估]
Tsitologiia. 1979 Jul;21(7):836-41.
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Some antigenic similarity between nonhistone protein-DNA complexes from chromatin of the cells of Zajdela hepatoma and liver of rats subjected to a single 4-dimethylaminoazobenzene injection.扎伊德拉伸肝癌细胞和单次注射4-二甲基氨基偶氮苯的大鼠肝脏染色质中的非组蛋白蛋白质-DNA复合物之间存在一些抗原相似性。
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