Stukalov S V, Chebotarev A N
Biull Eksp Biol Med. 1983 Dec;96(12):89-90.
Thiophosphamide is capable of inhibiting the cell cycle after the treatment of rabbit blood lymphocytes in vivo and in vitro. To assess the proliferative activity of the cells during cultivation, use was made of the index of the mean division number which was experienced by the cells after mutagenic exposure prior to fixation. As the mutagen dose was raised in vivo and in vitro, the mean division number decreased linearly, namely by approximately the same value with an equivalent dose variation. This indicates that thiophosphamide produces the same cytotoxic action both in vivo and in vitro.
硫磷酰胺在体内和体外处理兔血淋巴细胞后能够抑制细胞周期。为评估培养过程中细胞的增殖活性，采用了平均分裂数指数，该指数是细胞在固定前经诱变暴露后经历的平均分裂数。随着体内和体外诱变剂剂量的增加，平均分裂数呈线性下降，即在等效剂量变化时下降约相同的值。这表明硫磷酰胺在体内和体外产生相同的细胞毒性作用。
