Solomon S L, Khabbaz R F, Parker R H, Anderson R L, Geraghty M A, Furman R M, Martone W J
J Infect Dis. 1984 Jan;149(1):98-102. doi: 10.1093/infdis/149.1.98.
From July to September 1981, five patients at one hospital had bloodstream infections or colonization of an intravascular cannula with Candida parapsilosis. All five cases, but none of 34 controls, were receiving parenteral nutrition at the onset of infection or colonization (P less than 0.01; Fisher's exact test, one-tailed). Epidemiologic investigation showed that human serum albumin was more frequently added to parenteral nutrition solutions during the epidemic period than during a comparable period a year earlier. The increase in human serum albumin use coincided with the more frequent use of an electrically powered vacuum pump to assist in compounding parenteral nutrition solutions. Cultures from the vacuum pump showed heavy growth of C parapsilosis from multiple sites. Laboratory investigation demonstrated that sterile solutions could be contaminated by use of the vacuum pump. Use of the vacuum pump was stopped, and no further cases occurred.
1981年7月至9月期间，一家医院有5名患者发生血流感染或血管内插管被近平滑念珠菌定植。所有5例病例在感染或定植开始时均接受肠外营养，而34名对照者无一接受肠外营养（P<0.01；Fisher精确检验，单尾）。流行病学调查显示，与一年前的同期相比，在流行期间，人血清白蛋白更频繁地添加到肠外营养溶液中。人血清白蛋白使用量的增加与更频繁地使用电动真空泵辅助配制肠外营养溶液相吻合。真空泵的培养物显示多个部位有大量近平滑念珠菌生长。实验室调查表明，使用真空泵会污染无菌溶液。停止使用真空泵后，未再出现新的病例。
