Crisp A J, Coughlan R J, Mackintosh D, Clark B, Panayi G S
J Rheumatol. 1983 Dec;10(6):954-6.
Elevated plasma levels of beta 2 microglobulin have been described in rheumatoid arthritis (RA) but their relationship to disease activity is unclear. In patients treated for 6 months with auranofin (AF) there was a significant fall (p less than 0.05) in beta 2M levels pari passu with improvement in disease activity as measured by a fall in C-reactive protein. In addition, 26 patients with mild RA had beta 2M levels within the normal range. It is concluded that beta 2M plasma levels reflect disease activity in RA.
类风湿关节炎（RA）患者血浆β2微球蛋白水平升高已被报道，但它们与疾病活动的关系尚不清楚。在用金诺芬（AF）治疗6个月的患者中，β2M水平显著下降（p<0.05），同时疾病活动度改善，这可通过C反应蛋白下降来衡量。此外，26例轻度RA患者的β2M水平在正常范围内。结论是血浆β2M水平反映了RA的疾病活动度。
