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锂处理大鼠肾脏的形态学研究。

Morphological study of the kidneys of lithium treated rats.

作者信息

Mázló M, Pataky I, Szücs R

出版信息

Acta Morphol Hung. 1983;31(4):309-14.

PMID:6421093
Abstract

Short-term treatment of rats with low doses (2 meq/kg) of lithium carbonate led to renal damage which, however, appeared to be almost completely reversible even in nephrectomized animals. Renal damage caused by higher doses (6 meq/kg) was more explicit, but also appeared to be reversible to a certain degree even in the case of continuous lithium treatment. Regeneration was less expressed in nephrectomized animals. The collecting tubules and some segments of Henle's loop, as sites poor in mitochondria, display increased susceptibility to the damaging effect of lithium carbonate.

摘要

用低剂量(2 毫当量/千克)碳酸锂对大鼠进行短期治疗会导致肾损伤,不过,即使在肾切除的动物中,这种损伤似乎几乎完全可逆。高剂量(6 毫当量/千克)引起的肾损伤更明显,但即使在持续锂治疗的情况下,也似乎在一定程度上可逆。肾切除动物的再生表现较弱。集合小管和亨氏袢的一些节段作为线粒体含量少的部位,对碳酸锂的损伤作用敏感性增加。

相似文献

1
Morphological study of the kidneys of lithium treated rats.锂处理大鼠肾脏的形态学研究。
Acta Morphol Hung. 1983;31(4):309-14.
2
Effects of long-term lithium administration on renal structure and function in rats. A distinctive tubular lesion.长期给予锂对大鼠肾脏结构和功能的影响。一种独特的肾小管病变。
Lab Invest. 1984 May;50(5):526-35.
3
Lithium carbonate and the problem of kidney damage. Intracellular effects in rat kidney slices.碳酸锂与肾损伤问题。大鼠肾切片中的细胞内效应。
Arch Pathol Lab Med. 1983 May;107(5):270-3.
4
Ultrastructural and histochemical assessment of proximal renal tubule in rats during administration of lithium carbonate.碳酸锂给药期间大鼠近端肾小管的超微结构和组织化学评估
Mater Med Pol. 1989 Oct-Dec;21(4):280-5.
5
[Morphological changes in the kidneys under the effect of toxic doses of lithium chloride].[氯化锂中毒剂量作用下肾脏的形态学变化]
Vrach Delo. 1975 Jan(1):79-82.
6
[Side effects of low serum lithium concentrations on renal, thyroid, and sexual functions in male and female rats].[低血清锂浓度对雄性和雌性大鼠肾脏、甲状腺及性功能的副作用]
C R Biol. 2005 Oct-Nov;328(10-11):900-11. doi: 10.1016/j.crvi.2005.08.005. Epub 2005 Sep 26.
7
Experimental comparative renal toxicity of lithium and rubidium.锂和铷的实验性比较肾毒性
Drugs Exp Clin Res. 1985;11(4):269-73.
8
Lipid peroxidation as a possible mechanism for the neurotoxic and nephrotoxic effects of a combination of lithium carbonate and haloperidol.脂质过氧化作为碳酸锂和氟哌啶醇联用产生神经毒性和肾毒性作用的一种可能机制。
Arch Int Pharmacodyn Ther. 1985 Aug;276(2):301-12.
9
[Development of progeny after antenatal exposure to lithium oxybutyrate].[产前暴露于γ-羟基丁酸锂后子代的发育]
Farmakol Toksikol. 1985 Jan-Feb;48(1):73-6.
10
[Role of the kidneys in the pathogenesis of lithium poisoning].[肾脏在锂中毒发病机制中的作用]
Biull Eksp Biol Med. 1976 Dec;82(12):1426-8.

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