Nyberg G, Panfilov V, Sivertsson R
Int J Clin Pharmacol Ther Toxicol. 1984 Feb;22(2):91-5.
Nitroglycerin ointment (Nitrong 2%, 5 cm) and an identical placebo ointment were tested in a double-blind crossover study in five healthy volunteers to determine its influence on heart rate, blood pressure, and venous distensibility during supine rest and at 45 degrees tilt. Two hours after administration, a significantly higher venous distensibility was observed with the active ointment than with placebo. There were insignificant changes in heart rate and blood pressure. Three of the five subjects experienced headache for 6 h or more after active ointment.
在一项双盲交叉研究中，对5名健康志愿者使用硝酸甘油软膏（2%的Nitrong，5厘米）和一种相同的安慰剂软膏进行测试，以确定其在仰卧休息和45度倾斜时对心率、血压和静脉扩张性的影响。给药两小时后，观察到使用活性软膏时的静脉扩张性明显高于使用安慰剂时。心率和血压的变化不显著。5名受试者中有3人在使用活性软膏后经历了6小时或更长时间的头痛。
