Fowler J F
Phys Med Biol. 1984 Feb;29(2):97-113. doi: 10.1088/0031-9155/29/2/002.
The contributions of radiobiology to radiotherapy in the past 40 years are reviewed, taking the work of Gray and Read on bean roots with high LET radiation as the starting point. The main impact has been strategic and didactic because methods of measuring parameters in patients so as to affect individual treatments have not yet been developed. Many patients are now being treated with radiotherapy who would have been considered unsuitable 40 years ago and the radiobiological reasons for these changes are discussed. Improvements that have occurred in radiotherapy are reviewed and some projections about future potential improvements are made.
本文以格雷和里德对高传能线密度辐射作用于菜豆根的研究为起点，回顾了放射生物学在过去40年对放射治疗的贡献。其主要影响体现在策略和教学方面，因为尚未开发出针对患者测量参数以影响个体化治疗的方法。现在许多接受放射治疗的患者在40年前会被认为不适合，本文讨论了这些变化的放射生物学原因。本文回顾了放射治疗中已出现的改进，并对未来可能的改进进行了一些预测。
