Fletcher G H
Int J Radiat Oncol Biol Phys. 1983 Jul;9(7):1073-82. doi: 10.1016/0360-3016(83)90399-1.
At mid-century radiotherapy was more an art than a science, but is presently based on radiobiological parameters and cell kinetics. This close interaction between basic scientific principles and clinical practice has been made possible because one can correlate quantitatively doses of irradiation with observed responses. First, a short historical review will be made because it gives a perspective for the understanding both of progress made and prevailing misconceptions. The important radiobiological parameters and cell kinetics will then be discussed in some detail to demonstrate that they should be thoroughly understood in their relationship to radiotherapy. The overall treatment planning must be based on the clinical applications of the main radiobiological parameters. The combined treatment with surgery, either pre- or postoperatively, and multiple daily fractionations will be used as examples. The teaching of radiobiology should be considerably expanded, not only for its own scientific merit but also to show how it applies to clinical situations. This should be reflected in the expansion of the board examination.
在本世纪中叶，放射治疗与其说是一门科学，不如说是一门艺术，但目前它是基于放射生物学参数和细胞动力学的。基础科学原理与临床实践之间的这种紧密互动之所以成为可能，是因为人们可以将照射剂量与观察到的反应进行定量关联。首先，将进行简短的历史回顾，因为它为理解所取得的进展和普遍存在的误解提供了一个视角。然后将详细讨论重要的放射生物学参数和细胞动力学，以表明它们与放射治疗的关系应该得到透彻理解。总体治疗计划必须基于主要放射生物学参数的临床应用。以手术的术前或术后联合治疗以及每日多次分割治疗为例。放射生物学的教学应该大幅扩展，这不仅是因为其自身的科学价值，还因为要展示它如何应用于临床情况。这应该体现在委员会考试的扩展中。
