Glass E J, Hume R, Lang M A, Forfar J O
Arch Dis Child. 1984 Feb;59(2):131-5. doi: 10.1136/adc.59.2.131.
Fifty nine infants of birthweight less than 1500 g were allocated alternately to initial total parenteral nutrition or to transpyloric feeding. Mortality was similar between the two groups. Ten of the 29 infants in the transpyloric group failed to establish full enteral nutrition during the first week of life. No beneficial effects on growth were shown in infants receiving parenteral nutrition. Acquired bacterial infection was higher in the parenteral group and associated with morbidity and mortality. Conjugated hyperbilirubinaemia occurred only in the parenterally fed infants. The incidence of necrotising enterocolitis was higher in the transpyloric group. Parenteral nutrition does not confer any appreciable benefit and because of greater complexity and higher risk of complications should be reserved for those infants in whom enteral feeding is impossible.
59名出生体重低于1500克的婴儿被交替分配接受初始全胃肠外营养或经幽门喂养。两组的死亡率相似。经幽门喂养组的29名婴儿中有10名在出生后第一周未能建立完全肠内营养。接受胃肠外营养的婴儿未显示出对生长有有益影响。胃肠外营养组的获得性细菌感染率更高,且与发病率和死亡率相关。结合胆红素血症仅发生在接受胃肠外营养的婴儿中。经幽门喂养组坏死性小肠结肠炎的发病率更高。胃肠外营养没有带来任何明显益处,并且由于其更复杂且并发症风险更高,应仅用于无法进行肠内喂养的婴儿。