de Oca J, Gomez Portilla A, Rodriguez Ortigosa C
Infusionsther Klin Ernahr. 1984 Feb;11(1):26-30.
A total of 34 cancer patients, all of them subjected to radical surgery of the stomach or large bowel were studied. Group I (n = 5) received during the first postoperative days total parenteral nutrition with a caloric support of 35-45 kcal/kg/day and 12,5 gr N in a 8,5% L-aminoacid solution (Freamine II). Group II (n = 9) received an isotonic solution of 3% L-aminoacid without caloric support. Serum amino acids (AA) were determined daily (Perkin-Elmer KLA-1 Analyzer), as well as nitrogen balance (NB) and serum albumin (Alb) on the preoperative, 1st, and 6th postoperative day: Both groups experienced a progressive increase of serum AA during the period of study. Group II showed levels of branched-AA significantly higher than group I, as well as the total of essential-AA. MET, GLY and PHE were considerably elevated in both groups. ALA did not change in group I showing subnormal values in group II. NB was significantly higher in group I, but none of the groups studied has recovered the initial values of Alb after six days of treatment.
共研究了34例癌症患者,他们均接受了胃或大肠根治性手术。第一组(n = 5)在术后头几天接受全胃肠外营养,热量支持为35 - 45千卡/千克/天,在8.5%的左旋氨基酸溶液(Freamine II)中含12.5克氮。第二组(n = 9)接受不含热量支持的3%左旋氨基酸等渗溶液。每天测定血清氨基酸(AA)(使用珀金埃尔默KLA - 1分析仪),并在术前、术后第1天和第6天测定氮平衡(NB)和血清白蛋白(Alb):两组在研究期间血清AA均呈逐渐升高趋势。第二组的支链氨基酸水平以及必需氨基酸总量显著高于第一组。两组中的蛋氨酸、甘氨酸和苯丙氨酸均显著升高。第一组中丙氨酸未变化,第二组中丙氨酸值低于正常。第一组的氮平衡显著更高,但在治疗6天后,所研究的两组均未恢复Alb的初始值。