小鼠对街狂犬病毒的抗性：通过检测第二代回交后代进行遗传分析，并在SJL/J和CBA/J小鼠中验证等位抗性基因
Murine resistance to street rabies virus: genetic analysis by testing second-backcross progeny and verification of allelic resistance genes in SJL/J and CBA/J mice.
作者信息
Lodmell D L, Chesebro B
出版信息
J Virol. 1984 May;50(2):359-62. doi: 10.1128/JVI.50.2.359-362.1984.
Abstract
Intraperitoneal challenge with street rabies virus of second-backcross offspring produced from susceptible females mated with either randomly selected or rabies-resistant first-backcross males indicated that murine resistance is under the influence of the concurrent presence of each of two segregating genes. Furthermore, the greater than or equal to 96% resistance of offspring produced from (SJL X CBA)F1 and (CBA X SJL)F1 hybrids crossed to susceptible A.SW or A/WySn mice demonstrated that resistance genes of SJL/J and CBA/J mice are allelic.
摘要
用街狂犬病毒对由易感雌性与随机选择的或抗狂犬病的第一代回交雄性交配产生的第二代回交后代进行腹腔内攻击，结果表明小鼠的抗性受两个分离基因同时存在的影响。此外，(SJL×CBA)F1和(CBA×SJL)F1杂种与易感的A.SW或A/WySn小鼠杂交产生的后代具有大于或等于96%的抗性，这表明SJL/J和CBA/J小鼠的抗性基因是等位基因。
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