Przybojewska B, Dziubałtowska E, Kowalski Z
Mutat Res. 1984 Mar;135(3):189-91. doi: 10.1016/0165-1218(84)90120-4.
The micronucleus test was used to study the mutagenic effects of ethyl acrylate and methyl acrylate. Investigated compounds were administered to Balb C male mice by i.p. injection in two doses, separated by a period of 24 h. Ethyl acrylate at doses of 225-1800 mg/kg, and methyl acrylate at doses of 37.5-300 mg/kg significantly induce chromosome damage resulting in micronuclei formation in bone marrow polychromatic erythrocytes. Both investigated compounds significantly decrease the ratio of polychromatic to normochromatic erythrocytes. Positive results provide evidence of clastogenic activity of ethyl acrylate and methyl acrylate.
微核试验用于研究丙烯酸乙酯和丙烯酸甲酯的致突变作用。将受试化合物以两种剂量经腹腔注射给予Balb C雄性小鼠，两次给药间隔24小时。剂量为225 - 1800 mg/kg的丙烯酸乙酯和剂量为37.5 - 300 mg/kg的丙烯酸甲酯可显著诱导染色体损伤，导致骨髓多染红细胞中微核形成。两种受试化合物均显著降低了多染红细胞与正染红细胞的比例。阳性结果证明了丙烯酸乙酯和丙烯酸甲酯的断裂剂活性。
