Schunter C, Held H, Schmülling R
Klin Wochenschr. 1978 Mar 15;56(6):305-7. doi: 10.1007/BF01489177.
In 10 patients who were treated with phenprocoumon (Marcumar) for thrombembolic diseases, we examined the influence of the combined therapy with diacepam (Valium) on the effect of the anticoagulant. After stopping the therapy with diacepam we saw a significant increase of the prothrombinetime (Quick) beyond the therapeutic level of 25%. By increasing the dosis of phenprocoumon the therapeutic level was achieved again not until after 8 days. The dosis needed for maintaining this level was on the average 32% higher than during the time of the therapy in which diacepam was used. Because of the increased thrombembolic risk, when going beyond the therapeutic level of the prothrombinetime, this interaction is of clinical importance.
在10例接受苯丙香豆素（Marcumar）治疗血栓栓塞性疾病的患者中，我们研究了地西泮（Valium）联合治疗对抗凝效果的影响。停用 地西泮治疗后，我们发现凝血酶原时间（Quick）显著延长，超过了25%的治疗水平。通过增加苯丙香豆素的剂量，直到8天后才再次达到治疗水平。维持该水平所需的剂量平均比使用地西泮治疗期间高32%。由于凝血酶原时间超过治疗水平会增加血栓栓塞风险，这种相互作用具有临床重要性。
