Kinawi A, Teller C
J Clin Chem Clin Biochem. 1978 May;16(5):313-4.
The influence of Diazepam and Nitrazepam on the anticoagulating activity of Phenprocoumon was studied in rats. It was found that the repeated oral application of Diazepam or Nitrazepam during the treatment with Phenprocoumon did not change the adjusted prothrombin time. The prothrombin time was considerably shortened when the application of Diazepam or Nitrazepam was stopped although Phenprocoumon was still applied. Furthermore, the influence of Chlordiazepoxid, Diazepam and Nitrazepam on the normal prothrombin time was studied. It was found that the treatment with benzodiazepine derivatives had no influence upon the prothrombin time, not only during the treatment, but also after the treatment was stopped.
在大鼠中研究了地西泮和硝西泮对苯丙香豆素抗凝活性的影响。结果发现，在苯丙香豆素治疗期间重复口服地西泮或硝西泮，并未改变调整后的凝血酶原时间。尽管仍在应用苯丙香豆素，但当停止应用地西泮或硝西泮时，凝血酶原时间显著缩短。此外，还研究了氯氮卓、地西泮和硝西泮对正常凝血酶原时间的影响。结果发现，苯二氮卓衍生物治疗不仅在治疗期间，而且在治疗停止后，对凝血酶原时间均无影响。
