Kinawi A, Baumgartl I
Arzneimittelforschung. 1976;26(11):2019-23.
The interaction of benzodiazepine derivatives with phenprocoumon (Marcumar) was investigated after a single dose of the combination of phenprocoumon/diazepoxide (Librium), phenprocoumon/diazepam (Valium) and phenprocoumon/nitrazepam (Mogadan) had been applied to rats. By means of the high pressure liquid chromatography (HPLC) the change of concentration of these pharmaceutical agents per unit time in serum was determined and related to the corresponding change of prothrombin-time. Hence it can be concluded that the benzodiazepine derivatives influence the distribution of phenprocoumon in the organism.
在给大鼠单次应用苯丙香豆素/地西泮（利眠宁）、苯丙香豆素/安定（安定）和苯丙香豆素/硝西泮（莫加丹）的组合后，研究了苯二氮䓬衍生物与苯丙香豆素（马库马尔）的相互作用。通过高压液相色谱法（HPLC）测定血清中这些药剂单位时间内浓度的变化，并将其与凝血酶原时间的相应变化相关联。因此可以得出结论，苯二氮䓬衍生物会影响苯丙香豆素在机体中的分布。
