Best R, Christian R, Lewis D A
Agents Actions. 1984 Feb;14(2):265-8. doi: 10.1007/BF01966651.
Freund's complete adjuvant prepared by grinding dried, heat killed Mycobacterium tuberculosis with liquid paraffin was investigated for particle size-weight distribution. Variations in the grinding times and preparative procedure had a marked effect on the arthritogenic action of the adjuvant in the rat. A satisfactory response in the injected foot was found only when the particle size was less than 19 microns and a secondary response in the non-injected foot required particles less than 10 microns in diameter.
对通过将干燥、热灭活的结核分枝杆菌与液体石蜡研磨制备的弗氏完全佐剂进行了粒度-重量分布研究。研磨时间和制备程序的变化对该佐剂在大鼠中的致关节炎作用有显著影响。仅当颗粒尺寸小于19微米时，在注射的足部才会出现满意的反应，而在未注射的足部出现二次反应则需要直径小于10微米的颗粒。
