关节炎大鼠血液中的蛋白酶和抗蛋白酶水平。
Protease and antiprotease levels in blood of arthritic rats.
作者信息
Parrott D P, Lewis D A
出版信息
Ann Rheum Dis. 1977 Apr;36(2):166-9. doi: 10.1136/ard.36.2.166.
Abstract
Protease, antiprotease, and acid phosphatase blood levels of adjuvant arthritic rats were determined. The protease levels appear to vary inversely with the antiprotease levels. Changes in the protease levels correspond closely to changes in the acid phosphatase levels. Thus it is likely that the lysosomes contribute to the proteases present in the blood. Administered cortisol appears to raise blood antiprotease levels in both normal and arthritic rats and this may reflect an anti-inflammatory action by this drug.
摘要
测定了佐剂性关节炎大鼠的蛋白酶、抗蛋白酶和酸性磷酸酶的血液水平。蛋白酶水平似乎与抗蛋白酶水平呈负相关。蛋白酶水平的变化与酸性磷酸酶水平的变化密切相关。因此，溶酶体很可能是血液中蛋白酶的来源。给予的皮质醇似乎能提高正常大鼠和关节炎大鼠的血液抗蛋白酶水平，这可能反映了该药物的抗炎作用。
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