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结核结节聚集体大小对大鼠佐剂性关节炎严重程度的影响。

Influence of tubercle aggregate size on severity of adjuvant arthritis in the rat.

作者信息

Liyanage S P, Currey H L, Vernon-Roberts B

出版信息

Ann Rheum Dis. 1975 Feb;34(1):49-53. doi: 10.1136/ard.34.1.49.

DOI:10.1136/ard.34.1.49
PMID:804868
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1006344/
Abstract

Incorporation into Freund's complete adjuvant of tuberculous aggregates smaller than 90 mum in size is essential to produce adjuvant arthritis in the rat, and this correlates with a significantly greater degree of cell-mediated immunity to tuberculous antigens produced by small aggregates (smaller than 90 mum), when compared with large (larger than 90 mum) aggregates. This requirement for small aggregates to render Freund's complete adjuvant arthritogenic is not paralleled by detectable differences in antimycobacterial humoral antibody production nor by a size-dependent requirement for a conventional adjuvant effect.

摘要

将小于90微米的结核性聚集体掺入弗氏完全佐剂中对于在大鼠中产生佐剂性关节炎至关重要，并且与小聚集体（小于90微米）产生的针对结核性抗原的细胞介导免疫程度相比，大聚集体（大于90微米）产生的细胞介导免疫程度明显更高。这种对小聚集体使弗氏完全佐剂具有致关节炎作用的需求，在抗分枝杆菌体液抗体产生方面没有可检测到的差异，也没有常规佐剂效应的大小依赖性需求与之平行。

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1
Influence of tubercle aggregate size on severity of adjuvant arthritis in the rat.结核结节聚集体大小对大鼠佐剂性关节炎严重程度的影响。
Ann Rheum Dis. 1975 Feb;34(1):49-53. doi: 10.1136/ard.34.1.49.
2
Proceedings: Influence of tubercle aggregate size on the severity of adjuvant arthritis in the rat.论文集：结核结节聚集体大小对大鼠佐剂性关节炎严重程度的影响
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引用本文的文献

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Professor Barrie Vernon-Roberts, AO, MD, BSc, PhD, FRCPath, FRCPA, FAOrthA (Hon), FRS.SA.巴利·弗农-罗伯茨教授，AO，医学博士，理学学士，哲学博士，FRCPath，FRCPA，FAOrthA（荣誉），FRS.SA。
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2
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Adjuvant polyarthritis in rats: is this a satisfactory model for screening anti-arthritic drugs?大鼠佐剂性多关节炎：这是一种用于筛选抗关节炎药物的理想模型吗？
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本文引用的文献

1
Studies of arthritis and other lesions induced in rats by injection of mycobacterial adjuvant. II. Evidence that the disease is a disseminated immunologic response to exogenous antigen.关于注射分枝杆菌佐剂诱导大鼠产生关节炎及其他病变的研究。II. 该疾病是对外源抗原的一种播散性免疫反应的证据。
J Immunol. 1960 Oct;85:403-17.
2
Antibody to mycobacterial antigens in adjuvant arthritis (AA). I. Relationship to disease and delayed hypersensitivity.佐剂性关节炎（AA）中抗分枝杆菌抗原的抗体。I. 与疾病和迟发型超敏反应的关系。
Arthritis Rheum. 1972 May-Jun;15(3):283-92. doi: 10.1002/art.1780150310.
3
Lymphocyte activation. I. Response of T and B lymphocytes to phytomitogens.淋巴细胞活化。I. T淋巴细胞和B淋巴细胞对植物有丝分裂原的反应。
Clin Exp Immunol. 1971 Oct;9(4):483-98.
4
Competence of thoracic duct cells in the transfer of adjuvant disease and delayed hypersensitivity. Evidence that mycobacterial components are required for the successful transfer of the disease.胸导管细胞在佐剂病转移和迟发型超敏反应中的作用。有证据表明，疾病的成功转移需要分枝杆菌成分。
Cell Immunol. 1972 Jan;3(1):78-87. doi: 10.1016/0008-8749(72)90228-6.
5
T and B cells in the blood and synovial fluid of rheumatoid patients.类风湿性关节炎患者血液和滑液中的T细胞和B细胞。
Ann Rheum Dis. 1974 Sep;33(5):430-4. doi: 10.1136/ard.33.5.430.
6
Inhibition of macrophage migration by a proteoglycan extracted from Kurloff cells of the guinea-pig.从豚鼠库尔洛夫细胞中提取的一种蛋白聚糖对巨噬细胞迁移的抑制作用。
Int Arch Allergy Appl Immunol. 1972;43(6):813-25. doi: 10.1159/000230899.
7
Immunogenicity and arthritogenicity in the rat of an antigen from Mycobacterium tuberculosis wax D.结核分枝杆菌蜡质D抗原在大鼠体内的免疫原性和致关节炎性。
J Immunol. 1973 Aug;111(2):599-608.
8
Suppression of experimentally induced polyarthritis in the rat by heterologous anti-lymphocyte serum.异种抗淋巴细胞血清对大鼠实验性诱导多关节炎的抑制作用。
Lancet. 1966 Oct 22;2(7469):889-91. doi: 10.1016/s0140-6736(66)91984-2.