结核结节聚集体大小对大鼠佐剂性关节炎严重程度的影响。
Influence of tubercle aggregate size on severity of adjuvant arthritis in the rat.
作者信息
Liyanage S P, Currey H L, Vernon-Roberts B
出版信息
Ann Rheum Dis. 1975 Feb;34(1):49-53. doi: 10.1136/ard.34.1.49.
Abstract
Incorporation into Freund's complete adjuvant of tuberculous aggregates smaller than 90 mum in size is essential to produce adjuvant arthritis in the rat, and this correlates with a significantly greater degree of cell-mediated immunity to tuberculous antigens produced by small aggregates (smaller than 90 mum), when compared with large (larger than 90 mum) aggregates. This requirement for small aggregates to render Freund's complete adjuvant arthritogenic is not paralleled by detectable differences in antimycobacterial humoral antibody production nor by a size-dependent requirement for a conventional adjuvant effect.
摘要
将小于90微米的结核性聚集体掺入弗氏完全佐剂中对于在大鼠中产生佐剂性关节炎至关重要，并且与小聚集体（小于90微米）产生的针对结核性抗原的细胞介导免疫程度相比，大聚集体（大于90微米）产生的细胞介导免疫程度明显更高。这种对小聚集体使弗氏完全佐剂具有致关节炎作用的需求，在抗分枝杆菌体液抗体产生方面没有可检测到的差异，也没有常规佐剂效应的大小依赖性需求与之平行。
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