Montanaro A, Pirofsky B
Am J Med. 1984 Mar 30;76(3A):67-72. doi: 10.1016/0002-9343(84)90322-x.
Intravenous immunoglobulin can be a very effective form of treatment for patients with primary immunodeficiency states. Recommendations for intravenous dosing previously have been empirically derived. In order to determine the potential prolongation of intervals between infusions following the administration of 500 mg/kg of intravenous immunoglobulin, 11 patients were studied. This high-dose therapy was well tolerated and resulted in a modest prolongation of therapeutic IgG levels when compared with lower-dose 150 mg/kg regimens. Significant variability among individual patients was observed. Implications of this high-dose therapy are discussed.
静脉注射免疫球蛋白对原发性免疫缺陷状态患者可能是一种非常有效的治疗方式。此前静脉给药的推荐剂量是根据经验得出的。为了确定给予500mg/kg静脉注射免疫球蛋白后输注间隔时间的潜在延长情况，对11名患者进行了研究。与较低剂量150mg/kg方案相比，这种高剂量疗法耐受性良好，且能适度延长治疗性IgG水平。观察到个体患者之间存在显著差异。本文讨论了这种高剂量疗法的意义。
