Pitchon H, Glassock R, Kalmanson G M, Guze L B
Am J Pathol. 1984 Apr;115(1):25-30.
The course of experimental hematogenous pyelonephritis due to Streptococcus faecalis was compared in athymic (nu/nu) mice and euthymic (nu/+) littermates. Up to 7 weeks following infection, there were no significant differences in renal microbial populations. At 63 and 107-131 days there was significant escalation of infection in nu/nu mice, while the nu/+ mice were decreasing their infections. There was no increase in gross abscess formation in nu/nu mice, but in late stages significantly more gross scarring occurred in nu/nu as compared with nu/+ mice. Microscopically there was also greater scarring in nu/nu mice late in the disease, except for calyceal lesions. The data suggest that immunologic factors (T cells) are involved in the pathogenesis of chronic pyelonephritis.
对无胸腺（nu/nu）小鼠和有胸腺（nu/+）同窝小鼠因粪链球菌引起的实验性血源性肾盂肾炎病程进行了比较。感染后长达7周，肾脏微生物菌群无显著差异。在63天以及107 - 131天，nu/nu小鼠的感染显著加剧，而nu/+小鼠的感染则在减轻。nu/nu小鼠并未出现肉眼可见的脓肿形成增加，但在疾病后期，与nu/+小鼠相比，nu/nu小鼠出现了显著更多的肉眼可见瘢痕。显微镜检查显示，在疾病后期nu/nu小鼠除肾盂病变外也出现了更多瘢痕。数据表明免疫因素（T细胞）参与了慢性肾盂肾炎的发病机制。
