山梨酸对黄曲霉毒素B1和T-2毒素产生的刺激作用。
Stimulation of aflatoxin B1 and T-2 toxin production by sorbic acid.
作者信息
Gareis M, Bauer J, von Montgelas A, Gedek B
出版信息
Appl Environ Microbiol. 1984 Feb;47(2):416-8. doi: 10.1128/aem.47.2.416-418.1984.
Abstract
Aspergillus flavus grown on yeast extract-sucrose medium produced higher amounts of aflatoxin B1 in the presence of 0.025% sorbic acid than without this chemical with a maximum at 17 days of incubation. Addition of 0.05 to 0.0125% sorbic acid stimulated T-2 toxin production of Fusarium acuminatum cultures grown on maize meal. The highest amounts of the mycotoxin were detected in 14-day-old cultures containing 0.025% sorbic acid. It is assumed that certain amounts of sorbic acid near the minimal inhibitory concentration reduce the activity of the tricarboxylic acid cycle; this may lead to an accumulation of acetyl coenzyme A, which is an essential intermediate in the biosynthesis of aflatoxin B1 and T-2 toxin.
摘要
在酵母提取物 - 蔗糖培养基上生长的黄曲霉，在存在0.025%山梨酸的情况下，比没有这种化学物质时产生更高量的黄曲霉毒素B1，在培养17天时达到最大值。添加0.05%至0.0125%的山梨酸刺激了在玉米粉上生长的锐顶镰刀菌培养物中T - 2毒素的产生。在含有0.025%山梨酸的14天龄培养物中检测到最高量的霉菌毒素。据推测，接近最低抑菌浓度的一定量山梨酸会降低三羧酸循环的活性；这可能导致乙酰辅酶A的积累，而乙酰辅酶A是黄曲霉毒素B1和T - 2毒素生物合成中的必需中间体。
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