三羧酸循环中间体及相关代谢产物对黄曲霉静止细胞合成黄曲霉毒素的影响。
Influence of tricarboxylic acid cycle intermediates and related metabolites on the biosynthesis of aflatoxin by resting cells of Aspergillus flavus.
作者信息
Shantha T, Murthy V S
出版信息
Appl Environ Microbiol. 1981 Nov;42(5):758-61. doi: 10.1128/aem.42.5.758-761.1981.
Abstract
Resting cells of Aspergillus flavus synthesized aflatoxin from acetate as the sole carbon source after 36 h of incubation. Addition of pyruvate (5.5 mg/m) as cosubstrate to [1-14C]acetate and unlabeled acetate considerably reduced toxin production but increased the radioactivity on the tricarboxylic acid intermediates. This suggests that high tricarboxylic acid activity drastically affected toxin synthesis.
摘要
黄曲霉的静止细胞在以乙酸盐作为唯一碳源培养36小时后合成了黄曲霉毒素。向[1-¹⁴C]乙酸盐和未标记的乙酸盐中添加丙酮酸（5.5毫克/米）作为共底物，显著降低了毒素产量，但增加了三羧酸中间体上的放射性。这表明高三羧酸活性对毒素合成产生了极大影响。
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