Grosso L E, Pitot H C
Biochem Biophys Res Commun. 1984 Mar 15;119(2):473-80. doi: 10.1016/s0006-291x(84)80273-9.
A decrease in the expression of the myc proto-oncogene of HL-60 cells has been reported as an accompaniment of myeloid differentiation induced by either dimethylsulfoxide or retinoic acid. We report herein that several inhibitors of poly(ADP-ribose)-polymerase induced myeloid differentiation in HL-60 cultures. Studies on the expression of the c-myc gene in total cell RNA populations indicate that expression of this gene is inversely correlated with the state of differentiation, either myeloid or monocytic, of the cultured cells independent of the inducer and the rate of cell proliferation.
据报道，HL-60细胞的myc原癌基因表达下降是由二甲基亚砜或视黄酸诱导的髓系分化的一个伴随现象。我们在此报告，几种聚（ADP-核糖）聚合酶抑制剂在HL-60培养物中诱导了髓系分化。对总细胞RNA群体中c-myc基因表达的研究表明，该基因的表达与培养细胞的髓系或单核细胞分化状态呈负相关，与诱导剂和细胞增殖速率无关。
