Prowse C V, Farrugia A, Boulton F E, Tucker J, Ludlam C A, McLaren M, Belch J J, Prentice C R, Dawes J, MacGregor I R
Thromb Haemost. 1984 Feb 28;51(1):110-4.
In a group of six normal male volunteers, infusion of DDAVP, venous occlusion and exercise were shown to increase plasma levels of factor VIII and plasminogen activator, activity and antigen, to different extents and at differing rates. Any mechanisms suggested to explain release of these proteins by various stimuli should account for such differences. All three stimuli could also increase plasma levels of prostacyclin metabolites, although this was only significant for high doses of DDAVP. Other potential endothelial markers, such as fibronectin and thrombospondin, showed no specific increase after any of the stimuli.
在一组六名正常男性志愿者中，输注去氨加压素、静脉阻塞和运动均显示可不同程度、以不同速率增加血浆中因子VIII和纤溶酶原激活物的活性及抗原水平。任何用于解释这些蛋白质因各种刺激而释放的机制都应能说明这些差异。所有这三种刺激也均可增加血浆中前列环素代谢产物的水平，不过这仅在高剂量去氨加压素时才具有显著性。其他潜在的内皮标志物，如纤连蛋白和血小板反应蛋白，在任何刺激后均未显示出特异性增加。
