短杆菌肽A与二棕榈酰磷脂酰胆碱脂质体相互作用的拉曼光谱研究。
Raman spectroscopic investigation of the interaction of gramicidin A with dipalmitoyl phosphatidylcholine liposomes.
作者信息
Weidekamm E, Bamberg E, Brdiczka D, Wildermuth G, Macco F, Lehmann W, Weber R
出版信息
Biochim Biophys Acta. 1977 Jan 21;464(2):442-7. doi: 10.1016/0005-2736(77)90017-7.
PMID:64262
Abstract
The interaction of gramicidin A with dipalmitoyl phosphatidylcholine liposomes is investigated by Laser-Raman spectroscopy. As revealed by the methylene C-H stretching mode the phase transition of the hydrocarbon chains near 40 degree C is eliminated in the presence of gramicidin A. Liposomes prepared from a mixture of lecithin and cholesterol seem to be unaffected by gramicidin A and show only the normal broadened phase transition.
摘要
用激光拉曼光谱研究了短杆菌肽A与二棕榈酰磷脂酰胆碱脂质体的相互作用。由亚甲基C-H伸缩振动模式显示，在短杆菌肽A存在下，烃链在40℃附近的相变被消除。由卵磷脂和胆固醇混合物制备的脂质体似乎不受短杆菌肽A的影响，仅显示正常展宽的相变。
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