静脉输注Ca-EDTA后血浆、红细胞和尿液中的铅和锌浓度与δ-氨基乙酰丙酸脱水酶（ALA-D）活性的关系。
Lead and zinc concentrations in plasma, erythrocytes, and urine in relation to ALA-D activity after intravenous infusion of Ca-EDTA.
作者信息
Ishihara N, Shiojima S, Hasegawa K
出版信息
Br J Ind Med. 1984 May;41(2):235-40. doi: 10.1136/oem.41.2.235.
Lead and zinc concentrations in plasma, erythrocytes, and urine, urinary ALA concentration, and ALA-D activity in blood were studied for four hours in two male lead workers during and after a one hour infusion of Ca-EDTA 2Na. Urinary and plasma lead concentrations increased as a result of administering Ca-EDTA 2Na, and the ratios of lead concentrations in plasma to those in urine were greatly increased. The increase of plasma lead concentration was not due to the haemolytic effect of Ca-EDTA 2Na but was mobilised lead, rapidly excreted in the urine. ALA-D activity in blood increased at the end of the experiment with a transient decrease during the infusion of Ca-EDTA 2Na. As zinc concentrations in erythrocytes and plasma did not decrease during the infusion despite an increase in the urinary excretion of zinc, the transient decrease of ALA-D activity was not due to a loss of zinc caused by Ca-EDTA 2Na. From the results of additional experiments in vitro, this transient decrease could be related neither to Ca-EDTA 2Na nor to lead in the blood.
在两名男性铅作业工人中，研究了在静脉输注1小时Ca-EDTA 2Na期间及之后4小时内血浆、红细胞和尿液中的铅和锌浓度、尿中δ-氨基乙酰丙酸（ALA）浓度以及血液中ALA脱水酶（ALA-D）活性。给予Ca-EDTA 2Na后，尿铅和血浆铅浓度升高，血浆铅浓度与尿铅浓度之比大幅增加。血浆铅浓度的升高并非由于Ca-EDTA 2Na的溶血作用，而是被动员出来的铅，并迅速经尿液排出。实验结束时血液中ALA-D活性增加，而在输注Ca-EDTA 2Na期间有短暂下降。尽管尿锌排泄增加，但输注期间红细胞和血浆中的锌浓度并未降低，因此ALA-D活性的短暂下降并非由Ca-EDTA 2Na导致的锌流失所致。根据体外额外实验的结果，这种短暂下降既与Ca-EDTA 2Na无关，也与血液中的铅无关。
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