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钙螯合剂可增强牛磺酸从脑切片中的外流。

Calcium chelators enhance the efflux of taurine from brain slices.

作者信息

Korpi E R, Oja S S

出版信息

Neuropharmacology. 1984 Mar;23(3):377-80. doi: 10.1016/0028-3908(84)90202-8.

DOI:10.1016/0028-3908(84)90202-8
PMID:6427650
Abstract

Efflux of exogenous [3H]taurine from superfused slices of cerebral cortex of rat was enhanced by the calcium chelators EDTA and EGTA and by large concentrations of unlabelled taurine and histidine. The enhancement by EDTA and EGTA could be totally blocked by excess calcium, but that by the amino acids only partially. The enhancement of spontaneous taurine release in the absence of calcium complicates the assessment of the calcium dependence of evoked taurine release.

摘要

钙螯合剂乙二胺四乙酸(EDTA)和乙二醇双四乙酸(EGTA)以及高浓度的未标记牛磺酸和组氨酸可增强大鼠大脑皮层灌流切片中外源性[³H]牛磺酸的流出。EDTA和EGTA所引起的增强作用可被过量的钙完全阻断,但氨基酸所引起的增强作用只能被部分阻断。在无钙情况下自发牛磺酸释放的增强使对诱发牛磺酸释放的钙依赖性评估变得复杂。

相似文献

1
Calcium chelators enhance the efflux of taurine from brain slices.钙螯合剂可增强牛磺酸从脑切片中的外流。
Neuropharmacology. 1984 Mar;23(3):377-80. doi: 10.1016/0028-3908(84)90202-8.
2
Taurine efflux and the regulation of cell volume in incubated slices of rat cerebral cortex.牛磺酸外流与大鼠大脑皮层孵育切片中细胞体积的调节
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Tetanus toxin does not affect the release of noradrenaline and taurine from rat cerebral cortex slices evoked by high K+ and Na+-free media.破伤风毒素不影响高钾和无钠培养基诱发的大鼠大脑皮层切片中去甲肾上腺素和牛磺酸的释放。
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Modulation of noradrenaline uptake and release by taurine in rat cerebral slices.牛磺酸对大鼠脑片去甲肾上腺素摄取和释放的调节作用。
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Uptake and release of taurine from rat brain slices.大鼠脑切片中牛磺酸的摄取与释放
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引用本文的文献

1
Characteristics of hippocampal glycine release in cell-damaging conditions in the adult and developing mouse.成年和发育中小鼠细胞损伤条件下海马甘氨酸释放的特征
Neurochem Res. 2001 Jul;26(7):845-52. doi: 10.1023/a:1011624421505.
2
Release of preloaded taurine and hypotaurine from astrocytes in primary culture: stimulation by calcium-free media.原代培养星形胶质细胞中预负载的牛磺酸和亚牛磺酸的释放:无钙培养基的刺激作用
Neurochem Res. 1985 Jan;10(1):123-31. doi: 10.1007/BF00964777.
3
Depolarization of the neuronal membrane caused by cotransport of taurine and sodium.
牛磺酸与钠协同转运导致神经元膜去极化。
Neurochem Res. 1990 Jan;15(1):89-94. doi: 10.1007/BF00969189.