Korpi E R, Oja S S
Neuropharmacology. 1984 Mar;23(3):377-80. doi: 10.1016/0028-3908(84)90202-8.
Efflux of exogenous [3H]taurine from superfused slices of cerebral cortex of rat was enhanced by the calcium chelators EDTA and EGTA and by large concentrations of unlabelled taurine and histidine. The enhancement by EDTA and EGTA could be totally blocked by excess calcium, but that by the amino acids only partially. The enhancement of spontaneous taurine release in the absence of calcium complicates the assessment of the calcium dependence of evoked taurine release.
钙螯合剂乙二胺四乙酸(EDTA)和乙二醇双四乙酸(EGTA)以及高浓度的未标记牛磺酸和组氨酸可增强大鼠大脑皮层灌流切片中外源性[³H]牛磺酸的流出。EDTA和EGTA所引起的增强作用可被过量的钙完全阻断,但氨基酸所引起的增强作用只能被部分阻断。在无钙情况下自发牛磺酸释放的增强使对诱发牛磺酸释放的钙依赖性评估变得复杂。