Kontro P, Korpi E R, Oja O S, Oja S S
Neuroscience. 1984 Nov;13(3):663-6. doi: 10.1016/0306-4522(84)90086-1.
The effects of taurine on the uptake and release of noradrenaline were studied in forebrain slices from control rats and from rats treated with a taurine-free diet supplemented with 2-guanidinoethanesulphonate. Exogenous taurine slightly increased noradrenaline uptake in slices from untreated rats. There were no significant effects by exogenous taurine on spontaneous efflux of noradrenaline. The potassium-stimulated noradrenaline release was enhanced by taurine from frontal cortical slices and suppressed from occipital slices but only in the diet group, in which the endogenous brain taurine concentration had been lowered to one-half of the control concentration. It is suggested that taurine may act via presynaptic alpha-adrenoceptors and/or modify the availability of calcium for the stimulus-secretion coupling process.
研究了牛磺酸对正常大鼠及食用不含牛磺酸但补充了2-胍基乙磺酸盐的饮食的大鼠前脑切片中去甲肾上腺素摄取和释放的影响。外源性牛磺酸使未处理大鼠切片中的去甲肾上腺素摄取略有增加。外源性牛磺酸对去甲肾上腺素的自发外流没有显著影响。牛磺酸增强了额叶皮质切片中钾刺激的去甲肾上腺素释放，但抑制了枕叶切片中的释放，不过仅在饮食组中出现这种情况，该组内源性脑牛磺酸浓度已降至对照浓度的一半。提示牛磺酸可能通过突触前α-肾上腺素能受体起作用和/或改变刺激-分泌偶联过程中钙的可用性。
