Minguetti G, Ratton J F
Arq Neuropsiquiatr. 1984 Mar;42(1):59-63. doi: 10.1590/s0004-282x1984000100011.
Chagas' disease is a major problem in Central and South America. The disease is caused by Trypanosoma cruzi, a protozoon which may inhabit the blood and tissues of both man and animals. Although it may produce marked enlargement of several hollow viscera, myocardial involvement is the hallmark of chronic Chagas' disease. The clinical picture of chronic Chagas myocardites is one of insidious, progressive, prolonged congestive heart failure and cardiac enlargement. The almost invariable arrhythmias make syncope and sudden death common in patients both with p6 without congestive heart failure. Electrocardiographic abnormalities occur in 87 percent of patients with chronic Chagas' disease and are often the initial manifestation of illness . Pathological findings include mural trombosis which often results in pulmonary and central nervous system embolization. Trypanosoma cruzi is in general transmitted to human beings by the bite of haematophagus insects of the reduviidae family, but in the last years reports pointing out the importance of blood transfusions as infectious sources of Trypanosoma cruzi are becoming more and more frequent. The authors present a case of a male young architect which contrated Chagas' disease probably by a blood transfusion and latter developed "locked-in" syndrome. It is discussed the importance of blood transfusion as a source of transmission of the disease even in non-endemic areas and the need to controlling all blood transfusions in countries where Chagas' disease is endemic. The authors also point out the importance of computed tomography in the diagnosis of lesions in the pons.
恰加斯病是中美洲和南美洲的一个主要问题。该疾病由克氏锥虫引起,这是一种可寄生于人和动物血液及组织中的原生动物。尽管它可能导致多个中空脏器明显肿大,但心肌受累是慢性恰加斯病的标志。慢性恰加斯心肌病的临床表现是隐匿性、进行性、长期的充血性心力衰竭和心脏扩大。几乎不可避免的心律失常使晕厥和猝死在有或没有充血性心力衰竭的患者中都很常见。87%的慢性恰加斯病患者存在心电图异常,且常常是疾病的初始表现。病理结果包括壁血栓形成,这常导致肺栓塞和中枢神经系统栓塞。克氏锥虫通常通过猎蝽科吸血昆虫的叮咬传播给人类,但近年来,指出输血作为克氏锥虫传染源重要性的报告越来越多。作者介绍了一例年轻男性建筑师的病例,他可能因输血感染了恰加斯病,后来发展为“闭锁综合征”。文中讨论了即使在非流行地区输血作为疾病传播源的重要性,以及在恰加斯病流行国家控制所有输血的必要性。作者还指出了计算机断层扫描在脑桥病变诊断中的重要性。