Kaldor J, Speed B R
Br Med J (Clin Res Ed). 1984 Jun 23;288(6434):1867-70. doi: 10.1136/bmj.288.6434.1867.
The association between Campylobacter jejuni infection and Guillain-Barré syndrome was investigated serologically in a retrospective study of 56 patients admitted to this hospital over four years. Evidence of preceding C jejuni infection was found in 21 (38%) of these patients, indicating that C jejuni was the most common single identifiable pathogen precipitating the disease. Among those patients who had presented with preceding diarrhoea the serum antibody response was similar to that in uncomplicated C jejuni enteritis. Patients with serological evidence of preceding C jejuni infection manifested a significantly more severe form of the disease. In cerebrospinal fluid the predominant specific antibody class was IgG, and this was closely related to the serum titres of specific IgG. IgA and IgM specific antibodies were found only in the cerebrospinal fluid of patients with recent C jejuni infection. These findings support the possibility that humoral immune factors are responsible for the neural damage and demyelination seen in Guillain-Barré syndrome.
在一项为期四年的对本院收治的56例患者的回顾性研究中，通过血清学方法调查了空肠弯曲菌感染与吉兰 - 巴雷综合征之间的关联。在这些患者中有21例（38%）发现有先前空肠弯曲菌感染的证据，表明空肠弯曲菌是引发该疾病最常见的单一可识别病原体。在那些先前有腹泻症状的患者中，血清抗体反应与单纯空肠弯曲菌肠炎患者相似。有先前空肠弯曲菌感染血清学证据的患者表现出病情更为严重的形式。在脑脊液中，主要的特异性抗体类别是IgG，这与特异性IgG的血清滴度密切相关。仅在近期有空肠弯曲菌感染的患者脑脊液中发现了IgA和IgM特异性抗体。这些发现支持体液免疫因素导致吉兰 - 巴雷综合征中神经损伤和脱髓鞘的可能性。
