Lopez E, Tisserand-Jochem E M, Vidal B, Milet C, Lallier F, MacIntyre I
C R Acad Sci III. 1984;298(13):359-64.
Parathyrin of Stannius corpuscles (PCS), glands which are restricted to Holostei and Teleostei, is closely related to mammalian parathyrin (PTH) secreted by the parathyroids [( 6] to [9]). In unstimulated and stimulated CS we have shown the same structure and cellular types that are described in mammalian parathyroids. We observed three types of cells; the two sorts of cells already described [14] present such a difference of density (Fig. 1) that type I may be compared to chief dark cells and type II to chief light cells. The difference between these two forms was particularly marked in activated CS; a similar observation has been reported concerning PT [15]. Furthermore, we have detected a third type of cell present either singly in unactivated CS or in small groups between chief cells in activated CS. They showed all the characteristics of oxyphil cells [17]; they present an extremely dense cytoplasm with numerous mitochondria and a typical stellate form with cytoplasmic processes extending between chief cells (Figs. 2, 3). In CS of untreated eels, we have shown by means of indirect immunocytology (using an immunserum raised against the active fragment 1-34 bPTH) that the immunostained reaction product was limited to dilated cisternae and ribosomes of the rough endoplasmic reticulum and to most of the granules in all the chief cells (Figs. 4, 5). No immunoreaction was observed in Golgi area. Oxyphil cells did not present an immune localization of PCS. CS are structurally and cytologically similar to mammalian PT; furthermore their chief cells synthesize, stock and secrete a substance immunologically similar to mammalian PTH; the exact function of oxyphil cells has to be demonstrated.
斯坦尼氏小体（PCS）的甲状旁腺素，这种腺体仅存在于全骨鱼类和硬骨鱼类中，与甲状旁腺分泌的哺乳动物甲状旁腺素（PTH）密切相关[(6]至[9])。在未受刺激和受刺激的斯坦尼氏小体中，我们发现了与哺乳动物甲状旁腺中描述的相同结构和细胞类型。我们观察到三种类型的细胞；已经描述过的两种细胞[14]呈现出如此大的密度差异（图1），以至于I型细胞可与主暗细胞相比较，II型细胞可与主亮细胞相比较。这两种形式之间的差异在活化的斯坦尼氏小体中尤为明显；关于甲状旁腺也有类似的观察报告[15]。此外，我们检测到第三种类型的细胞，它要么单独存在于未活化的斯坦尼氏小体中，要么在活化的斯坦尼氏小体的主细胞之间成小群存在。它们表现出嗜酸性细胞的所有特征[17]；它们具有极其致密的细胞质，有许多线粒体，呈典型的星状形态，细胞质突起在主细胞之间延伸（图2、3）。在未处理的鳗鱼的斯坦尼氏小体中，我们通过间接免疫细胞化学方法（使用针对活性片段1 - 34 bPTH产生的免疫血清）表明，免疫染色反应产物仅限于粗面内质网的扩张池和核糖体以及所有主细胞中的大多数颗粒（图4、5）。在高尔基体区域未观察到免疫反应。嗜酸性细胞未呈现甲状旁腺素的免疫定位。斯坦尼氏小体在结构和细胞学上与哺乳动物的甲状旁腺相似；此外，它们的主细胞合成、储存和分泌一种在免疫学上与哺乳动物甲状旁腺素相似的物质；嗜酸性细胞的确切功能还有待证实。
