Durdey P, Bucknall T E
J R Soc Med. 1984 Jun;77(6):472-7.
Following injury, normal colon takes approximately 30 days to regain full breaking strength. This healing period can be lengthened by local infection. Colonic anastomoses are likely to be contaminated by intraluminal organisms, and suture material in such a situation is known to potentiate the development of sepsis. Experiments were designed to evaluate six suture materials used in colonic surgery to determine which retained adequate tensile strength and which excited least inflammatory response. The results indicate that absorbable sutures, with the exception of polydioxanone, lose strength too rapidly for use alone. Braided materials, notably silk, produce a prolonged tissue response and harbour bacteria. Monofilament materials are unreactive and appear least likely to delay healing. Polydioxanone, which is monofilament and absorbable, is recommended for use in the colon.
受伤后，正常结肠大约需要30天才能恢复全部抗断强度。局部感染会延长这一愈合期。结肠吻合口很可能被肠腔内的微生物污染，在这种情况下，缝合材料会促使败血症的发展。设计实验来评估用于结肠手术的六种缝合材料，以确定哪种材料能保持足够的拉伸强度，哪种材料引起的炎症反应最小。结果表明，除聚二氧六环酮外，可吸收缝线失去强度太快，不能单独使用。编织材料，尤其是丝线，会产生持久的组织反应并滋生细菌。单丝材料无反应，似乎最不可能延迟愈合。聚二氧六环酮是单丝且可吸收的，推荐用于结肠手术。
