Kon N D, Meredith J W, Poole G V, Martin M B, Kawamoto E, Myers R T
Am Surg. 1984 Oct;50(10):549-51.
A midline abdominal wound was made in 135 Harlan Sprague-Dawley rats, and the fascia was then closed by the continuous suture technique with 4-0 absorbable monofilament polydioxanone sutures (n = 45 rats), 4-0 permanent monofilament polypropylene sutures (n = 45 rats), or 4-0 Teflon-coated braided Dacron sutures (n = 45 rats). At 1-, 2-, and 6-month intervals, wound-bursting pressures were determined in 15 animals from each group. At 1 month and at 6 months, there was no significant difference in wound-bursting strength among the three types of sutures. At 2 months, wounds closed with Teflon-coated braided Dacron were significantly stronger than wounds closed with the other types of sutures. In most of the braided Dacron suture animals, the fascia burst in areas other than the abdominal wound, indicating that the wound was stronger at that time than was the surrounding fascia. There is no advantage to that added strength, and braided Dacron sutures have been shown to cause greater tissue reaction than monofilament sutures. Therefore, except in patients with poor wound healing who are highly susceptible to dehiscence and in whom permanent low-tissue-reaction sutures may be beneficial, the authors recommend a running suture technique using absorbable monofilament suture, such as polydioxanone, for the routine closure of clean abdominal wounds.
在135只Harlan Sprague-Dawley大鼠身上制作腹部正中切口，然后分别用4-0可吸收单丝聚二氧六环酮缝线（45只大鼠）、4-0永久性单丝聚丙烯缝线（45只大鼠）或4-0特氟龙涂层编织达克隆缝线（45只大鼠）通过连续缝合技术关闭筋膜。在1个月、2个月和6个月的时间间隔，每组选取15只动物测定伤口破裂压力。在1个月和6个月时，三种缝线类型的伤口破裂强度无显著差异。在2个月时，用特氟龙涂层编织达克隆缝线缝合的伤口明显比用其他类型缝线缝合的伤口更强。在大多数使用编织达克隆缝线的动物中，筋膜在腹部伤口以外的区域破裂，这表明此时伤口比周围的筋膜更强。这种额外的强度并无益处，而且已表明编织达克隆缝线比单丝缝线会引起更大的组织反应。因此，除了伤口愈合不良、极易发生裂开且使用永久性低组织反应缝线可能有益的患者外，作者建议对于清洁腹部伤口的常规缝合采用连续缝合技术，使用可吸收单丝缝线，如聚二氧六环酮。
