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[抗生素敏感性试验。凝胶扩散法与ATB法的多中心比较研究]

[Antibiotic sensitivity test. Comparative multicenter study of the gel diffusion and ATB methods].

作者信息

Gayral J P, Cluzel R, Miermont C, Pons M, Bismuth R, Bazire B, Lagrange P, Paul G, Duval J, Soussy C J

出版信息

Pathol Biol (Paris). 1984 May;32(5):347-50.

PMID:6429609
Abstract

The ATB method is a new method for antibiotic susceptibility testing. In a collaborative study, it was compared to a standard disc diffusion method. 23 strains were tested to determine reproducibility and 969 strains were used in the comparative study. Reproducibility of both methods is equivalent; differences due to strains were observed. Agreement between both methods is 87,9%, minor discrepancies are 8,7% and major discrepancies are 3,3%. Significant differences were found for carbenicillin and cefalotin and confirmed by MIC determination using the agar dilution method. Overall results show that the ATB method is reliable and comparable to disc diffusion for routine susceptibility testing.

摘要

ATB法是一种用于抗生素敏感性测试的新方法。在一项合作研究中,将其与标准纸片扩散法进行了比较。测试了23株菌株以确定重复性,并在比较研究中使用了969株菌株。两种方法的重复性相当;观察到因菌株不同而存在差异。两种方法的一致性为87.9%,轻微差异为8.7%,主要差异为3.3%。发现羧苄青霉素和头孢噻吩存在显著差异,并通过琼脂稀释法测定MIC得到证实。总体结果表明,ATB法可靠,在常规敏感性测试中可与纸片扩散法相媲美。

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