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[用于检测葡萄球菌对抗生素敏感性的Rapid-ATB系统评估。与琼脂稀释参考方法的比较]

[Evaluation of the Rapid-ATB system for testing the sensitivity of staphylococci to antibiotics. Comparison with the agar dilution reference method].

作者信息

Le Noc P, Carret G, Couix C, Flandrois J P, Gayral J P, Robert J

出版信息

Pathol Biol (Paris). 1986 Jun;34(5 Pt 2):600-3.

PMID:3534751
Abstract

Rapid ATB Staph is a new, automated, four-hour procedure for testing the susceptibility to antibiotics of staphylococci. Results obtained with this method were compared to those recorded using agar dilution. For all tested antibiotics as a group (5 on 201 strains, 8 on 100 strains), overall agreement between the two sets of results was 96%. 1,809 susceptibility tests were performed, with only 24 minor discrepancies (1.3%) mainly involving cotrimoxazole, and 50 major discrepancies (2.7%) mainly involving doxycycline and chloramphenicol. Rapid ATB Staph clearly demonstrates the heterogeneous oxacillin-resistance of staphylococci as well as their inducible resistance to erythromycin. Our results show that this new system is a very accurate means for testing the susceptibility to antibiotics of staphylococci.

摘要

快速葡萄球菌药敏试验是一种新型的、自动化的、耗时四小时的检测葡萄球菌对抗生素敏感性的方法。将该方法得到的结果与采用琼脂稀释法记录的结果进行了比较。对于所有作为一组进行测试的抗生素(对201株菌测试5种抗生素,对100株菌测试8种抗生素),两组结果的总体一致性为96%。共进行了1809次药敏试验,仅有24处微小差异(1.3%),主要涉及复方新诺明,以及50处主要差异(2.7%),主要涉及强力霉素和氯霉素。快速葡萄球菌药敏试验清楚地显示了葡萄球菌对苯唑西林耐药性的异质性及其对红霉素的诱导性耐药。我们的结果表明,这个新系统是检测葡萄球菌对抗生素敏感性的一种非常准确的方法。

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