Bäckström T, Zetterlund B, Blom S, Romano M
Acta Neurol Scand. 1984 Apr;69(4):240-8. doi: 10.1111/j.1600-0404.1984.tb07807.x.
Earlier work showed that in a group of women suffering from partial epilepsy, there is a decrease in seizure frequency during the luteal phase of the menstrual cycle. Moreover, iv progesterone infusions decrease the discharge frequency from penicillin epileptic foci in cats, when given in doses that reach plasma concentrations as observed during pregnancy. In the present study, iv progesterone infusions, reaching plasma concentrations as during the luteal phase, were given to 7 women with partial epilepsy. The inclusion criterion was that they should have more than one epileptic discharge per 5 min on an ordinary EEG . A 6 h EEG-registration was made. Blank and progesterone solutions were infused for 2 h respectively and the progesterone infusion was followed by a 2 h EEG recording period. 4 of the 7 patients showed a significant decrease in spike frequency during the infusion. In the patients not showing this effect, the plasma progesterone binding capacity was high. The 2 patients with the most marked progesterone effect had low progesterone binding capacity and no antiepileptic treatment. Somnolence during the test might also have influenced the results in 2 of the patients.
早期研究表明，在一组患有部分性癫痫的女性中，月经周期黄体期的癫痫发作频率会降低。此外，静脉注射孕酮，当给予达到孕期观察到的血浆浓度的剂量时，可降低猫青霉素癫痫病灶的放电频率。在本研究中，对7名患有部分性癫痫的女性静脉注射孕酮，使其达到黄体期的血浆浓度。纳入标准是她们在普通脑电图上每5分钟应出现不止一次癫痫放电。进行了6小时的脑电图记录。分别输注空白溶液和孕酮溶液2小时，然后在输注孕酮后进行2小时的脑电图记录期。7名患者中有4名在输注期间尖峰频率显著降低。在未显示出这种效果的患者中，血浆孕酮结合能力较高。孕酮作用最明显的2名患者孕酮结合能力较低且未接受抗癫痫治疗。测试期间的嗜睡也可能影响了2名患者的结果。
