Theodossi A, Spiegelhalter D J, McFarlane I G, Williams R
Br Med J (Clin Res Ed). 1984 Jul 28;289(6439):213-6. doi: 10.1136/bmj.289.6439.213.
Twelve doctors with special training in hepatology independently reviewed two to five cases each from a group of seven cases of complicated hepatobiliary problems. A doctor's willingness to take risks to improve his patients' health was quantified by a wagering technique based on the probability of achieving a successful intervention. These probabilities were then used to calculate "utilities," which represented the average opinion of the doctors about the relative worth of each of six predefined states of health. The results showed that, in the context of risky decisions for severely ill patients, a year of life was considered by the doctors to be worth 44% of a full recovery; being mobile for that year increased this value to 57%. Survival for up to five years with restricted mobility was considered to be worth 70% of a full recovery and the ability to work during that period increased this value to 85%. It is concluded that in clinical decision making the uncertainty and preferences implicit in a course of action can be quantified and thus made explicit.
十二位接受过肝病学专项培训的医生各自独立审查了一组七例复杂肝胆问题病例中的两到五例。通过一种基于成功干预概率的打赌技术,对医生为改善患者健康状况而承担风险的意愿进行了量化。然后,这些概率被用于计算“效用”,“效用”代表了医生对六种预定义健康状态中每一种相对价值的平均看法。结果显示,在针对重症患者的风险决策背景下,医生们认为一年的生命价值相当于完全康复价值的44%;如果在这一年里能够活动,这一价值会增至57%。活动受限但存活长达五年被认为价值相当于完全康复价值的70%,而在此期间能够工作则会将这一价值增至85%。研究得出结论,在临床决策中,一项行动中隐含的不确定性和偏好可以被量化,从而变得明确。