Pauker S G
Ann Intern Med. 1976 Jul;85(1):8-18. doi: 10.7326/0003-4819-85-1-8.
The choice between coronary by-pass surgery and medical therapy in patients with angiographically documented coronary artery disease was examined. This decision analysis included consideration of patient preferences, severity of disease, prognosis with medical therapy, surgical mortality rate, graft patency rate, the probability that surgery will provide both short-term and long-term pain relief, and the probability that surgery will alter long-term survival. Coronary surgery was found to be the preferred therapy in many patients with disabling angina; it was rarely found to be the preferred therapy in asymptomatic patients, even those with proximal obstruction of the left anterior descending coronary artery. The therapeutic decision was strongly affected by differences in patient attitudes and differences in the past results of the prospective surgeon. This paper presents both a data base and a methodology that allow the physician to apply decision analysis to individual patients with coronary artery disease.
对血管造影证实患有冠状动脉疾病的患者在冠状动脉搭桥手术和药物治疗之间的选择进行了研究。该决策分析包括考虑患者偏好、疾病严重程度、药物治疗的预后、手术死亡率、移植物通畅率、手术能提供短期和长期疼痛缓解的概率以及手术能改变长期生存率的概率。结果发现,冠状动脉手术是许多患有致残性心绞痛患者的首选治疗方法;而在无症状患者中,即使是那些左前降支冠状动脉近端阻塞的患者,很少发现冠状动脉手术是首选治疗方法。治疗决策受到患者态度差异和预期外科医生过去手术结果差异的强烈影响。本文介绍了一个数据库和一种方法,使医生能够将决策分析应用于个体冠状动脉疾病患者。