免疫球蛋白G重链同种异型（Gm），人类14号染色体长臂32区的一种遗传标记，与血液系统恶性肿瘤相关。
IgG heavy chain allotype (Gm), a genetic marker for human chromosome 14q32, and haematopoietic malignancies.
作者信息
Nakao Y, Matsumoto H, Tsuji K, Miyazaki T, Masaoka T, Nakayama S, Kinoshita K, Shingami T, Matsui T, Fujita T
出版信息
Clin Exp Immunol. 1984 Jun;56(3):628-36.
IgG heavy chain constant region allotypes, Gm, the genetic marker of human chromosome 14q32, are markers for susceptibility to certain diseases. We tested Gm allotypes in 365 patients with various types of haematological malignancies, 528 healthy controls and 35 healthy HTLV carriers. The frequency of specific Gm phenotypes was significantly increased in patients with adult onset null-ALL, AML, AMoL and CML in blastic crisis. Among these diseases, the frequency of Gm1,2,21 haplotype was significantly increased with adult onset null-ALL, AML and AMoL.
免疫球蛋白G重链恒定区同种异型（Gm）是人类14号染色体长臂32区的遗传标记，是某些疾病易感性的标记。我们检测了365例各种类型血液系统恶性肿瘤患者、528例健康对照者和35例健康人嗜人T淋巴细胞病毒携带者的Gm同种异型。在成人型无丙种球蛋白血症、急性髓系白血病、急性单核细胞白血病和急变期慢性髓系白血病患者中，特定Gm表型的频率显著增加。在这些疾病中，Gm1,2,21单倍型在成人型无丙种球蛋白血症、急性髓系白血病和急性单核细胞白血病中的频率显著增加。
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