Gm同种异型与斑秃的抗性和易感性相关。
Gm allotype associated resistance and susceptibility to alopecia areata.
作者信息
Galbraith G M, Thiers B H, Pandey J P
出版信息
Clin Exp Immunol. 1984 Apr;56(1):149-52.
Abstract
IgG heavy chain (Gm) and kappa light chain (Km) allotypes were determined in 42 Caucasian patients with alopecia areata. There was a significant increase in frequency of Gm 1,2,3,17;5,13,21 (P less than 0.001), and a significant decrease in frequency of Gm 1,3,17;5,13,21 (P = 0.009), when results were compared to those of 105 normal healthy Caucasians from the same geographic area. These results can be explained by postulating dominant disease susceptibility and resistance genes in significant linkage disequilibrium with the haplotypes Gm1,2,17;21 and Gm1,17;21, respectively.
摘要
对42名患有斑秃的白种人患者测定了IgG重链（Gm）和κ轻链（Km）同种异型。将结果与来自同一地理区域的105名正常健康白种人相比，Gm 1,2,3,17;5,13,21的频率显著增加（P小于0.001），而Gm 1,3,17;5,13,21的频率显著降低（P = 0.009）。这些结果可以通过假设分别与单倍型Gm1,2,17;21和Gm1,17;21处于显著连锁不平衡状态的显性疾病易感性和抗性基因来解释。
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